Many chemotherapies are P-gp substrates, and can only be given intravenously

• Selective and very potent P-gp inhibitor
• Minimal systemic bioavailability

Encequidar is designed to allow for oral absorption of chemotherapy agents such as paclitaxel.

• Minimal systemic absorption
• Localized P-gp inhibitory activity in GI tract
• No significant systemic side effects to other organs & cells seen in clinical studies
• Expect lower incidence of severe toxicities associated with IV intravenous infusion